Overshoot of FVIII Activity in Patients with Acquired Hemophilia

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Effect of Fviii Co-administrated with Ivig in Immunity to Fviii in Hemophilia a Mice Effect of Fviii Co-administrated with Ivig in Immunity to Fviii in Hemophilia a Mice

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Identification of FVIII gene mutations in patients with hemophilia A using new combinatorial sequencing by hybridization

BACKGROUND Standard methods of mutation detection are time consuming in Hemophilia A (HA) rendering their application unavailable in some analysis such as prenatal diagnosis. OBJECTIVES To evaluate the feasibility of combinatorial sequencing-by-hybridization (cSBH) as an alternative and reliable tool for mutation detection in FVIII gene. PATIENTS/METHODS We have applied a new method of cSBH...

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Proteolytic antibodies activate factor IX in patients with acquired hemophilia.

Acquired hemophilia is a rare bleeding disorder characterized by the spontaneous occurrence of inhibitory antibodies against endogenous factor VIII (FVIII). IgG from some patients with acquired hemophilia hydrolyze FVIII. Because of the complex etiology of the disease, no clinical parameter, including the presence of FVIII-hydrolyzing IgG, has been associated with patient's survival or death. H...

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ژورنال

عنوان ژورنال: Blood

سال: 2018

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2018-99-112126